"I say, sin being a transgression of God’s law, which was made for man’s good, the sinfulness of sin must needs lie in this, that it is contrary (1) to God, (2) to man."

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1) "Carnal men, or sinners, are called by the name of enemies to God (Romans 5:8, 10; Colossians 1.21); but the carnal mind or sin is called enmity itself (Romans 8:7)."

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2) "Sin is contrary to all the names and attributes of God. It sets itself in opposition to them all: 

• It denies God’s all-sufficiency. As if there were not contentment and satisfaction enough to be had in the enjoyment of God… Every prodigal who leaves the Father’s house says in effect, it is better to be elsewhere. 

• It challenges the justice of God, and dares God to do his worst (Malachi 2.17). It provokes the Lord to jealousy, and tempts him to wrath. 

• It disowns his omniscience. Pooh! they say, God does not see, nor does the most High regard.

3) "Sin is contrary to the works of God. It works contrary to God, and it is contrary to God’s works, and is called the work of the devil (1 John 3:8)."

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4) "Sin is an anti-will to God’s will; it sets itself to oppose preaching, prayer, and all the institutions of God. And it does this, not only out of envy to man, that he should not be the better for them, but out of enmity to God, that he should not be worshipped in the world." 

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5) "It is against man’s well-being in this life. Well-being is the life of life, and sin bears us so much ill-will, that it deprives us of our livelihood, and of that which makes it worth our while to live."

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6) "There is a resurrection to life for the righteous, the children of the resurrection; and for the wicked a resurrection to condemnation or to death–for this is opposed to life (John 5.29). "

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"In this world there is a door of hope, a day, an offer, and means of grace, space for repentance, a Mediator in Heaven, a patient God, and a possibility of being blessed.

But once [condemned], the door is shut and it is in vain to knock."